. . . . . . . . . . . . . . . . . "a(SCHEM:Nadide) -> (cat(p(HGNC:SIRT1)) -| bp(GO:\"myoblast differentiation\"))" . "cat(p(HGNC:SIRT1)) -| bp(GO:\"myoblast differentiation\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "To inhibit myogenesis, Sir2 requires its NAD(+)-dependent deacetylase activity. The [NAD(+)]/[NADH] ratio decreases as muscle cells differentiate, while an increased [NAD(+)]/[NADH] ratio inhibits muscle gene expression. Cells with reduced Sir2 levels are less sensitive to the inhibition imposed by an elevated [NAD(+)]/[NADH] ratio. These results indicate that Sir2 regulates muscle gene expression and differentiation by possibly functioning as a redox sensor. In response to exercise, food intake, and starvation, Sir2 may sense modifications of the redox state and promptly modulate gene expression." . . "Selventa" . . . . "2014-07-03T14:30:15.187+02:00"^^ . . .