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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#_5 http://www.w3.org/ns/prov#value Furthermore, we identified three tyrosines (Tyr-1175, Tyr-1265, and Tyr-1294) within the kinase domain that play critical but overlapping roles in controlling constitutive Erk activation by mRon. Phenylalanine mutations at these three tyrosines results in a receptor that fails to constitutively activate the Erk pathway but retains the ability to induce Erk phosphorylation in response to ligand stimulation. The ability of mRon to activate the MAP kinase pathway is dependent on c-Src activity, and we have shown that c-Src co-immunoprecipitates with mRon. c-Src fails to interact with mRon when the three tyrosines required for MAP kinase activation are mutated, whereas the presence of any one of these tyrosines alone restores Erk phosphorylation and recruitment of c-Src. http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16103119 http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16103119 http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#_5 http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE http://purl.org/dc/terms/created 2014-07-03T14:30:37.638+02:00 http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnvBfR0hoFe0x9M-NRd_0uUUIPFz849x58jQfzIzBkjE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234