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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#_5 http://www.w3.org/ns/prov#value Plasminogen activator inhibitor type-1 (PAI-1), competes with alphavbeta3 integrin for vitronectin (VN) binding. Here we report that PAI-1, in a VN-dependent manner, prevents the cooperation of alphavbeta3 integrin with insulin signaling in NIH3T3 fibroblasts, resulting in a decrease in insulin-induced protein kinase B (PKB) phosphorylation, vascular endothelial growth factor (VEGF) expression and cell migration http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12603314 http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12603314 http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#_5 http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs http://purl.org/dc/terms/created 2014-07-03T14:30:10.494+02:00 http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAoMGiG6f4ZcidOrT_MVNfcUKC4W6xYNnUDxh8fYBqCZs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234