@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAoOyc2LrdtzPT5nYexP2x5IOaPtPGghDUNZMvZHlqRqo> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAoOyc2LrdtzPT5nYexP2x5IOaPtPGghDUNZMvZHlqRqo#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: mgi:1337040;
    a Protein: .
  
  sub:_3 occursIn: species:10090;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:22868;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:\"bile salt\") -> tscript(p(MGI:Nr1i2))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "consistent with this proposal, all Lxr target genes encode proteins that have major roles in controlling cholesterol and or fatty acid homeostasis in a number of tissues including the liver, intestine, macrophages and possibly adipose tissue primary bile acids, such as CDCA or CA, bind to Fxr in vitro, this interaction occurs at physiological levels of the bile acids this interaction results in recruitment of coactivators to the liganded Fxr, and that there is a subsequent increase in the transcription of target genes Fxr transcripts are restricted to the liver, kidney, intestine [all involved in cholesterol/bile acid metabolism], colon, and adrenals";
    prov:wasQuotedFrom pubmed:11792716 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11792716;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:30:00.279+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}