sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "1.4" .
  sub:_3 prov:value "Recently published data have revealed rapid up-regulation of Akt activity in isolated skeletal muscle subjected to passive stretch, which appears specific to fast-twitch muscle (Sakamoto et al. 2003). The stretch-induced activation of Akt is completely blocked through pretreatment with wortmannin, an inhibitor of PI3K. In other studies phosphorylation of both 4E-BP1 and S6K1 has been shown to be enhanced in response to muscle loading (Baar & Esser, 1999; Bodine et al. 2001; Nader & Esser, 2001; Rommel et al. 2001) and positively contributes to the up-regulation of select gene expression necessary to elicit long-term increases in skeletal muscle accretion." ;
    prov:wasQuotedFrom pubmed:15294054 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15294054 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}