sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Figure 5. Regulation of the core cell-death machinery by E2F-1 and the p53 family. E2F-1 can regulate apoptosis in many ways. It can induce cell death by stabilizing the levels of p53 through activating the ARF tumor suppressor, which suppresses Mdm2, a negative regulator of p53. The p53 protein regulates the transcription of several celldeath genes including BH3-only proteins, proapoptotic Bcl-2 protein Bax and the caspase-9 adaptor Apaf-1. In cells lacking p53, E2F-1 can act through p73, a member of p53 family that activates some of the same target genes as p53. E2F-1 can also directly regulate the transcription of several different caspases and suppress cell survival pathways by suppressing Mcl-1 expression or by inhibiting NFkB-mediated antiapoptotic signaling." ;
    prov:wasQuotedFrom pubmed:15082313 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15082313 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}