@prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dct: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix mgi: . @prefix proteinModification: . @prefix psimod: . @prefix go: . @prefix Protein: . @prefix geneProductOf: . @prefix hasAgent: . @prefix schem: . @prefix species: . @prefix occursIn: . @prefix mesh: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 belv:variantOf mgi:1333863; a proteinModification:, psimod:00696 . sub:_2 hasAgent: sub:_3; a go:0003824 . sub:_3 geneProductOf: mgi:1333863; a Protein: . sub:_4 rdf:object schem:cyclic%20AMP; rdf:predicate belv:directlyDecreases; rdf:subject sub:_2; a rdf:Statement . sub:_5 occursIn: mesh:D017667, species:10090; rdf:object sub:_4; rdf:predicate belv:decreases; rdf:subject sub:_1; a rdf:Statement . sub:assertion rdfs:label "cat(p(MGI:Pde3b)) =| a(SCHEM:\"cyclic AMP\")", "p(MGI:Pde3b,pmod(P)) -| (cat(p(MGI:Pde3b)) =| a(SCHEM:\"cyclic AMP\"))" . } sub:provenance { beldoc: dce:description "Approximately 61,000 statements."; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved."; dce:title "BEL Framework Large Corpus Document"; pav:authoredBy sub:_8; pav:version "1.4" . sub:_6 dce:identifier "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10"; dce:title "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10"; dce:type "Book" . sub:_7 prov:value "p277 However, protein kinase A phosphorylation of the cell surface receptors leads to uncoupled G-protein activity and heterologous desensitization to both the glucagon and catecholamine signals. It is also relevant that protein kinase A can phosphorylate and thereby activate cGMP-inhibited phosphodiesterase which cleaves cAMP and probably helps modulate its effects to minimize desensitization"; prov:wasQuotedFrom sub:_6 . sub:_8 rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource sub:_6; prov:wasDerivedFrom beldoc:, sub:_7 . } sub:pubinfo { this: dct:created "2014-07-03T14:29:45.564+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }