sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "1.4" .
  sub:_2 prov:value "Furthermore, integrin ?1?1-null mice have been shown to be deficient in tumour angiogenesis42. The reason for this is thought to be that the expression of matrix metalloproteinase (MMP)-9 is elevated in the absence of ?1?1, which normally suppresses MMP-9 expression.As a result, more angiostatin - a peptide that suppresses angiogenesis - is produced by MMP-9- catalysed proteolytic cleavage of plasminogen. So, the pathways through which these integrins affect angiogenesis might be different from those used by ?v?3,?v?5 and ?5?1." ;
    prov:wasQuotedFrom pubmed:12635171 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12635171 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}