. . . . . . . . . . "a(SCHEM:Angiostatin) -| bp(GO:angiogenesis)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Furthermore, integrin ?1?1-null mice have been shown to be deficient in tumour angiogenesis42. The reason for this is thought to be that the expression of matrix metalloproteinase (MMP)-9 is elevated in the absence of ?1?1, which normally suppresses MMP-9 expression.As a result, more angiostatin - a peptide that suppresses angiogenesis - is produced by MMP-9- catalysed proteolytic cleavage of plasminogen. So, the pathways through which these integrins affect angiogenesis might be different from those used by ?v?3,?v?5 and ?5?1." . . "Selventa" . . . . "2014-07-03T14:30:10.924+02:00"^^ . . .