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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#_3 http://www.w3.org/ns/prov#value In this study, we found TPA-induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter.We then identified a Sp1 binding site located -77 to -68 from the ATG that is a TPA-responsive element (TRE) of the promoter and that Sp1, Sp2, and Sp3 proteins bind to the TRE.We also found that the binding of these proteins to the TRE was significantly increased by TPA treatment and inhibition of the binding by mithramycin A decreased TPA-induced promoter activity as well as 8S-LOX mRNA expression. These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter. http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14711820 http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14711820 http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#_3 http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg http://purl.org/dc/terms/created 2014-07-03T14:30:19.509+02:00 http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAorOEWTlQEtdd0lII4CwHhbAFyBgs6nWJwJZwNGj2kYg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234