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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#_5 http://www.w3.org/ns/prov#value Progressive insulin resistance in MKO mice Body weights were similar in control and MKO mice at 6 and 14 months of age (Table 1). Basal glucose levels were measured every two months (data not shown); values were the same among all groups at 6 and 14 months of age (Table 1). Basal insulin levels, measured throughout the lifetime of these animals, were significantly elevated in MKOfl/fl compared with controlfl/fl mice as early as 6 months of age (P = 0.0004). There was a nonsignificant increase in basal levels of free fatty acids (FFA; 20?25%) in both MKO groups, (and these differences were amplified during the glucose clamp study) (see below). Triglyceride levels were significantly elevated in both MKO groups compared with controls (approx1.5-fold; P = 0.001) by 14 months of age (Table 1). At 14 months, the absence of one Pparg allele in the controlfl/- mice caused a significant reduction (33%; P = 0.035) in plasma Acrp-30 (adipocyte complement-related protein, 30 kDa). http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14625542 http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14625542 http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#_5 http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M#pubinfo http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M http://purl.org/dc/terms/created 2014-07-03T14:30:18.436+02:00 http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAoxHQXxWma6OGUHswSK-qZQESPVqK8al9bTlCrhhNF3M http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234