http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#Head http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#provenance http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#pubinfo http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D018482 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0050981 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://purl.bioontology.org/ontology/MSH/D015444 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.w3.org/2000/01/rdf-schema#label bp(MESHPP:Exercise) -> bp(GO:"detection of electrical stimulus") http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_2 http://www.w3.org/ns/prov#value Activation of nuclear CaMKII and MEF2 To test for changes in CaMKII phosphorylation, fibers were stimulated with a 5-s duration 10-Hz train every 50 s for 1 h with or without 5 microM KN-62 in the Ringer's solution and fixed and stained with primary antibody to activated (autophosphorylated; Fig. 3 A, open bars) or total (Fig. 3 A, filled bars) CaMKII. 1 h of 10-Hz train stimulation significantly increased (P less than 0.01) the mean nuclear stain of activated CaMKII compared with unstimulated fibers, and KN-62 (5 microM) blocked the increase in activated CaMKII staining after stimulation (Fig. 3 A). In parallel experiments, in which the fibers were stained with antibody directed against total CaMKII, there was no difference in mean nuclear antibody stain between stimulated and unstimulated fibers (P greater than 0.05; Fig. 3 A). These results are consistent with activation of nuclear CaMKII by fiber electrical stimulation without any appreciable translocation of CaMKII from the cytoplasm to the nucleus. http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15767461 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15767461 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#_2 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc#pubinfo http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://purl.org/dc/terms/created 2014-07-03T14:30:33.443+02:00 http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RApSBhogB2yn0TeGnLujDvfIl_TRAgTFbZOPEd6E0EoNc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234