. . . . . . . . . . . . "a(SCHEM:Thiazolidinedione) -| r(HGNC:RETN)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "However, the combination of antibodies to TNFa, IL-6, and IL-1b markedly attenuated LPS induction of resistin (Figure 3C). These data clearly show that resistin induction by endotoxin is mediated by a cascade in which the primary event is secretion of inflammatory cytokines that, in turn, induce resistin. Induction of Resistin Is Blocked by Anti-Inflammatory Insulin-Sensitizing Drugs That Target NF-kB Mouse resistin, produced exclusively by adipocytes, is down-regulated by antidiabetic thiazolidinediones, including rosiglitazone [11]. Consistent with an earlier report [16], rosiglitazone down-regulated resistin gene expression (Figure 4A) in LPS-stimulated human macrophages. Resistin protein secretion was also significantly reduced by rosiglitazone (Figure 4B). Hence, macrophage expression of resistin and its induction by LPS is species-specific, but down-regulation of resistin by thiazolidinedione occurs both in rodents and humans." . . "Selventa" . . . . "2014-07-03T14:30:30.031+02:00"^^ . . .