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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#_3 http://www.w3.org/ns/prov#value However, the combination of antibodies to TNFa, IL-6, and IL-1b markedly attenuated LPS induction of resistin (Figure 3C). These data clearly show that resistin induction by endotoxin is mediated by a cascade in which the primary event is secretion of inflammatory cytokines that, in turn, induce resistin. Induction of Resistin Is Blocked by Anti-Inflammatory Insulin-Sensitizing Drugs That Target NF-kB Mouse resistin, produced exclusively by adipocytes, is down-regulated by antidiabetic thiazolidinediones, including rosiglitazone [11]. Consistent with an earlier report [16], rosiglitazone down-regulated resistin gene expression (Figure 4A) in LPS-stimulated human macrophages. Resistin protein secretion was also significantly reduced by rosiglitazone (Figure 4B). Hence, macrophage expression of resistin and its induction by LPS is species-specific, but down-regulation of resistin by thiazolidinedione occurs both in rodents and humans. http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15578112 http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15578112 http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#_3 http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY#pubinfo http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY http://purl.org/dc/terms/created 2014-07-03T14:30:30.031+02:00 http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RApUhOv01VY96Y89A63CfibdybIaWtZ14aPbGCCuvKAUY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234