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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#_2 http://www.w3.org/ns/prov#value Adipose tissue also functions as an endocrine organ, secreting hormones and cytokines that regulate metabolism in other tissues. Given these key roles of the adipocyte in regulating overall energy balance, an understanding of the molecular and cellular biology of the fat cell will be required to understand fully the causes of diabetes and obesity, and to develop therapies for their treatment. Here, we review recent advances in our knowledge of the generation of adipocytes by adipogenesis and of the physiology of mature adipocytes. Control of adipocyte differentiation Obesity is characterized by increased adipose tissue mass that results from both increased fat-cell number (hyperplasia) and increased fat-cell size (hypertrophy) [4]. http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12223316 http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12223316 http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#_2 http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM http://purl.org/dc/terms/created 2014-07-03T14:30:05.693+02:00 http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAphYH08-_WYvKDmnHxsxVoYAtP6rMqGGnLFeG2vr4EjM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234