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complex(p(PFR:"Hdac Class II Family"),p(PFR:"Mef2 Family")) -| bp(GO:"myoblast differentiation")
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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Skeletal muscle differentiation is controlled by associations between myogenic basic-helix-loop-helix and MEF2 transcription factors. We show that chromatin associated with muscle genes regulated by these transcription factors becomes acetylated during myogenesis and that class II histone deacetylases (HDACs), which interact with MEF2, specifically suppress myoblast differentiation.
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Selventa
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2014-07-03T14:29:52.350+02:00
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