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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#_5 http://www.w3.org/ns/prov#value Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10871856 http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10871856 http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#_5 http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns#pubinfo http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns http://purl.org/dc/terms/created 2014-07-03T14:29:51.445+02:00 http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RApypumsbAO6-402ekvdicnisbPsbeZlqGafw0UwMjJns http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234