http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#Head http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#provenance http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_2 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6877 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_1 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/Advanced%20Glycation%20End%20Product http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"Advanced Glycation End Product") -> kin(p(HGNC:MAPK3)) http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_4 http://www.w3.org/ns/prov#value However, using an inhibitor of ERK activation, U0126, we show that Alb-AGE stimulates VEGF expression through an ERK-dependent pathway. Accordingly, we found that Alb-AGE activated mitogen-activate protein kinase, ERK1/2, JNK1/2, but not p38, and that Alb-AGE did not activate PI3K and PKB. Moreover, Alb-AGE activated the transcription factor, hypoxia inducible factor-1 (HIF-1) DNA binding activity. This activation is mediated by an increase in accumulation of the HIF-1alpha protein through an ERK-dependent pathway. http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11571295 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11571295 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#_4 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://purl.org/dc/terms/created 2014-07-03T14:29:58.291+02:00 http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAq1rC0pMmhdEKBwiUpzn2o64dRhgMQMDEThdxaZpFCZI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234