[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_1",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:88512"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_1"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/increases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://amigo.geneontology.org/amigo/term/GO:0006953"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "bp(GO:\"acute-phase response\") -> p(MGI:Crp)"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_4"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "1.4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_3",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "C-reactive protein (CRP) and serum amyloid P component (SAP) are acute phase proteins, whose concentrations increase within 24 h of inflammation along with concentration of IL-8. Polymorphonuclear neutrophil leukocytes (PMNs) form the earliest barrier protecting an injured organ during acute phase response. The aim of present work was to study interactions between CRP, SAP and IL-8, and to estimate the role of these interactions in regulation of neutrophil transendothelial migration. The results have shown that IL-8 binds to immobilized but not to free CRP. Binding of IL-8 to immobilized SAP was less strong. SAP like IL-8 increased CD11/CD18 integrin expression. IL-8 did not abolish the effect of SAP, and the mixture of IL-8 and SAP has stimulated CD11/CD18 expression. CRP upregulated CD18 but not CD11b expression. Under simultaneous action of CRP and IL-8, the stimulatory effect on CD11b and CD18 was abolished. The expression of fibronectin receptor was reduced by either IL-8 or CRP but increased by SAP. Effect of each protein was downregulated after following preincubations: CRP+SAP, CRP+IL-8 or SAP+IL-8. The mixtures of CRP with SAP, CRP with IL-8 or SAP with IL-8 showed no chemotactic activity, although each of the proteins was chemoattractive. Thus, acute phase proteins and IL-8 can act as anti-inflammatory factors upon binding each other. In summary, CRP and SAP influence PMN adhesion, migration and expression of CD11b/CD18 and fibronectin receptors, and can modulate the action of IL-8 on PMN attachment to endothelium and fibronectin, and on PMN traffic through the extracellular matrix during transendothelial migration."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12687191"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_4",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12687191"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_3"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:30:11.669+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#pubinfo"
} ]