http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#Head http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#provenance http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88512 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_1 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0006953 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"acute-phase response") -> p(MGI:Crp) http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_3 http://www.w3.org/ns/prov#value C-reactive protein (CRP) and serum amyloid P component (SAP) are acute phase proteins, whose concentrations increase within 24 h of inflammation along with concentration of IL-8. Polymorphonuclear neutrophil leukocytes (PMNs) form the earliest barrier protecting an injured organ during acute phase response. The aim of present work was to study interactions between CRP, SAP and IL-8, and to estimate the role of these interactions in regulation of neutrophil transendothelial migration. The results have shown that IL-8 binds to immobilized but not to free CRP. Binding of IL-8 to immobilized SAP was less strong. SAP like IL-8 increased CD11/CD18 integrin expression. IL-8 did not abolish the effect of SAP, and the mixture of IL-8 and SAP has stimulated CD11/CD18 expression. CRP upregulated CD18 but not CD11b expression. Under simultaneous action of CRP and IL-8, the stimulatory effect on CD11b and CD18 was abolished. The expression of fibronectin receptor was reduced by either IL-8 or CRP but increased by SAP. Effect of each protein was downregulated after following preincubations: CRP+SAP, CRP+IL-8 or SAP+IL-8. The mixtures of CRP with SAP, CRP with IL-8 or SAP with IL-8 showed no chemotactic activity, although each of the proteins was chemoattractive. Thus, acute phase proteins and IL-8 can act as anti-inflammatory factors upon binding each other. In summary, CRP and SAP influence PMN adhesion, migration and expression of CD11b/CD18 and fibronectin receptors, and can modulate the action of IL-8 on PMN attachment to endothelium and fibronectin, and on PMN traffic through the extracellular matrix during transendothelial migration. http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12687191 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12687191 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#_3 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://purl.org/dc/terms/created 2014-07-03T14:30:11.669+02:00 http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqHtVGkKtP4e7s-wzrzZRdaHfZLVCqi0LYYIJsrpdaHg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234