sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Intracellular [Ca2+] increases in ischemic areas (487), partly due to overactivation of NMDA receptors; MAP2 and alpha-spectrin (fodrin) are degraded in animal models of cerebral ischemia with the calpain-specific 150-kDa alpha-spectrin fragment appearing 5 (28) or 60 min (319) after ischemia in rat brains; rate of expansion of the area of spectrin degradation is reduced by synthetic calpain inhibitors, A275 and A295 (28). Calpastatin is degraded by calpain to a membrane-bound 50-kDa polypeptide in ischemic brain (41). Tissue damage in ischemic areas involves both apoptosis and necrosis and the calpains participate in both processes" ;
    prov:wasQuotedFrom pubmed:12843408 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12843408 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}