. . . . . . . . . . . . . "path(MESHD:Ischemia) -> cat(p(HGNC:GRINA))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Intracellular [Ca2+] increases in ischemic areas (487), partly due to overactivation of NMDA receptors; MAP2 and alpha-spectrin (fodrin) are degraded in animal models of cerebral ischemia with the calpain-specific 150-kDa alpha-spectrin fragment appearing 5 (28) or 60 min (319) after ischemia in rat brains; rate of expansion of the area of spectrin degradation is reduced by synthetic calpain inhibitors, A275 and A295 (28). Calpastatin is degraded by calpain to a membrane-bound 50-kDa polypeptide in ischemic brain (41). Tissue damage in ischemic areas involves both apoptosis and necrosis and the calpains participate in both processes" . . "Selventa" . . . . "2014-07-03T14:30:14.256+02:00"^^ . . .