@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:4923;
    a RNA: .
  
  sub:_2 occursIn: mesh:D001940, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:23965;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:estradiol) -> r(HGNC:HK2)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "1.4" .
  
  sub:_3 prov:value "In breast cancers, estrogen receptor (ER) levels are highly correlated with response to endocrine therapies. We sought to define mechanisms of estradiol (E) signaling in a solid breast tumor model using gene expression profiling. ER+ T47D-Y human breast cancer cells were grown as xenografts in ovariectomized nude mice under four conditions: i. E for 8 weeks (E); ii. without E for 8 weeks (controls, C); iii. E for 7 weeks followed by 1 week of E withdrawal (Ewd), or iv. E for 8 weeks with Tamoxifen for the last week (E+Tam). E-regulated genes were defined as those that differed significantly between C and E, and/or between E and Ewd. These protocols generated 188 in vivo E-regulated genes that showed two major patterns of regulation. Approximately 46% returned to basal states after Ewd (Class I genes); 53% did not (Class II genes). In addition, more than 70% of Class II regulated genes also failed to reverse in response to Tamoxifen. These genes may be interesting to study hormone resistance issues. A subset of in vivo E-regulated genes appears on lists of clinical  \\\"ER discriminator \\\" genes. These may be useful therapeutic targets or markers of E activity. Comparison of in vivo E-regulated genes to those regulated in identical cells in vitro after 6 and 24 h of E treatment demonstrate only 11% overlap. This indicates the extent to which gene expression profiles are uniquely dependent on hormone treatment times and the cellular microenvironment.";
    prov:wasQuotedFrom pubmed:16239301 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:16239301;
    prov:wasDerivedFrom beldoc:, sub:_3 .
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sub:pubinfo {
  this: dct:created "2014-07-03T14:30:38.913+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}