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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#_3 http://www.w3.org/ns/prov#value In breast cancers, estrogen receptor (ER) levels are highly correlated with response to endocrine therapies. We sought to define mechanisms of estradiol (E) signaling in a solid breast tumor model using gene expression profiling. ER+ T47D-Y human breast cancer cells were grown as xenografts in ovariectomized nude mice under four conditions: i. E for 8 weeks (E); ii. without E for 8 weeks (controls, C); iii. E for 7 weeks followed by 1 week of E withdrawal (Ewd), or iv. E for 8 weeks with Tamoxifen for the last week (E+Tam). E-regulated genes were defined as those that differed significantly between C and E, and/or between E and Ewd. These protocols generated 188 in vivo E-regulated genes that showed two major patterns of regulation. Approximately 46% returned to basal states after Ewd (Class I genes); 53% did not (Class II genes). In addition, more than 70% of Class II regulated genes also failed to reverse in response to Tamoxifen. These genes may be interesting to study hormone resistance issues. A subset of in vivo E-regulated genes appears on lists of clinical \"ER discriminator \" genes. These may be useful therapeutic targets or markers of E activity. Comparison of in vivo E-regulated genes to those regulated in identical cells in vitro after 6 and 24 h of E treatment demonstrate only 11% overlap. This indicates the extent to which gene expression profiles are uniquely dependent on hormone treatment times and the cellular microenvironment. http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16239301 http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16239301 http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#_3 http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug http://purl.org/dc/terms/created 2014-07-03T14:30:38.913+02:00 http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqNYKB85wTsMrw0Pw9ePGYXoJLs9HbrMMlK-p1RvH0ug http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234