http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#Head http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#provenance http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4603 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D008264 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_1 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://bioportal.bioontology.org/ontologies/MSH/D001424 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.w3.org/2000/01/rdf-schema#label path(SDIS:"bacterial infection") -> r(HGNC:CXCL2) http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_3 http://www.w3.org/ns/prov#value Understanding the response of innate immune cells to pathogens may provide insights to host defenses and the tactics used by pathogens to circumvent these defenses. We used DNA microarrays to explore the responses of human macrophages to a variety of bacteria. Macrophages responded to a broad range of bacteria with a robust, shared pattern of gene expression. The shared response includes genes encoding receptors, signal transduction molecules, and transcription factors. This shared activation program transforms the macrophage into a cell primed to interact with its environment and to mount an immune response. Further study revealed that the activation program is induced by bacterial components that are Toll-like receptor agonists, including lipopolysaccharide, lipoteichoic acid, muramyl dipeptide, and heat shock proteins. Pathogen-specific responses were also apparent in the macrophage expression profiles. Analysis of Mycobacterium tuberculosis-specific responses revealed inhibition of interleukin-12 production, suggesting one means by which this organism survives host defenses. These results improve our understanding of macrophage defenses, provide insights into mechanisms of pathogenesis, and suggest targets for therapeutic intervention. http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11805289 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11805289 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#_3 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://purl.org/dc/terms/created 2014-07-03T14:30:00.597+02:00 http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqPNlSrOVOZ80QM6aTFtrs2m2iRgH7QNEBTTeefHEl7s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234