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complex(a(SCHEM:Sirolimus),p(MGI:Fkbp1a)) -| complex(NCM:"Interleukin 4 Receptor Complex")
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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RAPA suppresses the functional activation of dendritic cells (DCs) both in vitro and in vivo.In vitro, RAPA inhibits IL-4-dependent maturation and T-cell stimulatory activity of murine bone marrow-derived DCs. These effects are associated with posttranscriptional down-regulation of both subunits of the IL-4 receptor complex (CD124, CD132) and are mediated via binding of RAPA to its intracellular receptor FK506-binding protein 12 (FKBP12).
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Selventa
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2014-07-03T14:30:09.452+02:00
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