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p(HGNC:NFKBIA) =| tscript(complex(NCH:"Nfkb Complex"))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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In most cell types, the NFkB p50-p65 dimer is bound to one of the closely related endogneous inhibitory proteins, collectively referred to as IkB, and is held inactive in the cyotplasm. A variety of extracellular signaling, including LPS, cytokines, stress factors have been reported to activate NFkb through phosphorylation of IkB at serine-32 and serine-36, dissociation of IkB from the complex, and translocation of the p50-p65 dimer fromt he cytolplasm to the nucleus.
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Selventa
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2014-07-03T14:30:15.038+02:00
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