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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqav1FMGUXeMnedmoG1LhmQQtIwv3QS0akKF8O8n-DC0#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAqav1FMGUXeMnedmoG1LhmQQtIwv3QS0akKF8O8n-DC0#_5 http://www.w3.org/ns/prov#value HRG induces the phosphorylation of BRCA1, peaking at 0.5 to 2 hours and returning to basal level thereafter. In order to determine whether Cdk4 phosphorylates BRCA1, wild type Cdk4 cDNA and the kinase dead mutant Cdk4-D158N were transiently overexpressed in T47D cells. After 48 hours, total cell lysates were prepared and subsequently immunoprecipitated with anti-Cdk4 antibodies following 2 hours of HRG stimulation. The immunoprecipitates were incubated with wild type BRCA1 or with c-terminal truncated BRCA1. 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