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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#_5 http://www.w3.org/ns/prov#value To understand how cells control E2F6 expression, we analysed the activity of the previously cloned promoter region of the human E2F6 gene. DNase I footprinting, gel electrophoreticmobility shift, transient transfection and site-directed mutagenesis experiments allowed the identification of two functional NRF-1/alpha-PAL (nuclear respiratory factor-1/alpha-palindrome-binding protein)-binding sites within the human E2F6 core promoter region, which are conserved in the mouse and rat E2F6 promoter region. Moreover, ChIP (chromatin immunoprecipitation) analysis demonstrated that overexpressed NRF-1/alpha-PAL is associated in vivo with the E2F6 promoter. Furthermore, overexpression of full-length NRF-1/alpha-PAL enhanced E2F6 promoter activity, whereas expression of its dominant-negative form reduced the promoter activity. Our results indicate that NRF-1/alpha-PAL is implicated in the regulation of basal E2F6 gene expression. http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15257658 http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15257658 http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#_5 http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ http://purl.org/dc/terms/created 2014-07-03T14:30:26.006+02:00 http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqb8nLKUW6mPCOquYYdrF5FGGMljUMCXiczYgYlTLwUQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234