sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "The ?v?3 integrin might also be a target for the antiangiogenic protein factors angiostatin, endostatin, antithrombin and anastellin45. Endostatin binds ?v?3 and forms complexes with fibulin and nidogen, angiostatin binds to fibrin and vitronectin, antithrombin complexes with thrombin and vitronectin, and anastellin forms polymers with fibronectin and fibrinogen. All of these proteins are bound by the anti-angiogenic factors and are components of the blood or ECM that contain RGD sequences that are recognized by ?v?3 (and/or by the other RGD-directed integrins, ?v?5 and ?5?1). These ?v?3-binding complexes could be anti-angiogenic through a shared mechanism that remains to be elucidated." ;
    prov:wasQuotedFrom pubmed:12635171 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12635171 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}