. . . . . . . . . . . . . "p(HGNC:ABL1) -> p(HGNC:CAT)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "The results demonstrate that catalase, a major effector of the cellular defence against hydrogen peroxide, interacts with c-Abl and Arg. The results show that hydrogen peroxide induced binding of c-Abl and Arg to catalase. The SH3 domains of c-Abl and Arg bound directly to catalase at a 293 PFNP296 site. c-Abl and Arg phosphorylated catalase at Tyr-231 and Tyr-386 in vitro and in the response of cells to Hydrogen peroxide. The functional significance of the interaction is supported by the demonstration that cells deficient in both c-Abl and Arg exhibit substantial increases in hydrogen peroxide levels. Cells expressing Myc-catalase and c-Abl also showed phosphorylation of catalase at tyrosine. By contrast, tyrosine phosphorylation of catalase was inhibited in cells expressing c-Abl (K-R-inactive mutant). Catalase was also subject to tyrosine phosphorylation in cells expressing kinase-active Arg, but not kinase-inactive Arg (K-R- inactive mutant). The deletion of catalase 293 PFNP296 site abrogates the interaction between ABL1 and catalase." . . "Selventa" . . . . "2014-07-03T14:30:12.942+02:00"^^ . . .