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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#_4 http://www.w3.org/ns/prov#value The results demonstrate that catalase, a major effector of the cellular defence against hydrogen peroxide, interacts with c-Abl and Arg. The results show that hydrogen peroxide induced binding of c-Abl and Arg to catalase. The SH3 domains of c-Abl and Arg bound directly to catalase at a 293 PFNP296 site. c-Abl and Arg phosphorylated catalase at Tyr-231 and Tyr-386 in vitro and in the response of cells to Hydrogen peroxide. The functional significance of the interaction is supported by the demonstration that cells deficient in both c-Abl and Arg exhibit substantial increases in hydrogen peroxide levels. Cells expressing Myc-catalase and c-Abl also showed phosphorylation of catalase at tyrosine. By contrast, tyrosine phosphorylation of catalase was inhibited in cells expressing c-Abl (K-R-inactive mutant). Catalase was also subject to tyrosine phosphorylation in cells expressing kinase-active Arg, but not kinase-inactive Arg (K-R- inactive mutant). The deletion of catalase 293 PFNP296 site abrogates the interaction between ABL1 and catalase. http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12777400 http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12777400 http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#_4 http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q http://purl.org/dc/terms/created 2014-07-03T14:30:12.942+02:00 http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArDm-xyBtNg3h7dT20d3hjMeghMjVutR-TwCSGIQOO6Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234