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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#_5 http://www.w3.org/ns/prov#value The Raf kinases serve as central intermediates to relay signals from Ras to ERK. Cell-specific effects of these signals on growth, differentiation and survival can be observed due to the recruitment of different isoenzymes of the Raf family. The in vitro phosphorylation of a site unique to B-Raf (Ser429) has been proposed to be responsible for the negative regulation of the isoenzyme by Akt. Using phosphopetide mapping and site-directed mutagenesis we showed that Ser429 is phosphorylated upon cAMP elevation in PC12 cells and proposed that PKA is a major kinase phosphorylating the B-Raf-specific site in vivo. http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11510412 http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11510412 http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#_5 http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI#pubinfo http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI http://purl.org/dc/terms/created 2014-07-03T14:29:57.872+02:00 http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArJ1mjWTCUSJ8Ol2hFprwi8RcGnnnAfxRywyJ-UfSkKI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234