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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#_5 http://www.w3.org/ns/prov#value In this study, we report that S100A8, S100A9, and S100A8/A9 caused neutrophil chemotaxis at concentrations of 10(-12)-10(-9) M. S100A8, S100A9, and S100A8/A9 stimulated shedding of L-selectin, up-regulated and activated Mac-1, and induced neutrophil adhesion to fibrinogen in vitro. As shown in Fig. 3, MRPs induced shedding of L-selectin (CD62L) from the neutrophil surface. In contrast, expression of CD11b, but not CD51 was up-regulated following stimulation with MRPs. As Mac-1 is stored in specific and gelatinase granules, this suggests that MRPs induced neutrophil degranulation. http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12626582 http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12626582 http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#_5 http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM#pubinfo http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM http://purl.org/dc/terms/created 2014-07-03T14:30:10.737+02:00 http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArLSzZrA3UeWLHrlUqF_bQUe7JUHxMiQMqPsN-DFpQDM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234