@prefix this: <http://www.tkuhn.ch/bel2nanopub/RArRCEUeIiH5ZXK7SyezxilGUn24s9brGlHverzzb9Dm0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RArRCEUeIiH5ZXK7SyezxilGUn24s9brGlHverzzb9Dm0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 hasPart: sub:_2 , sub:_3 ;
    a ProteinComplex: .
  sub:_2 geneProductOf: hgnc:12372 ;
    a Protein: .
  sub:_3 geneProductOf: hgnc:12373 ;
    a Protein: .
  sub:_4 hasAgent: sub:_5 ;
    a go:0003824 .
  sub:_5 geneProductOf: hgnc:12373 ;
    a Protein: .
  sub:_6 occursIn: species:9606 ;
    rdf:object sub:_4 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "complex(p(HGNC:TSHB),p(HGNC:TSHR)) -> cat(p(HGNC:TSHR))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "1.4" .
  sub:_7 prov:value "In human thyroid tissue, the ligand-independent activation of the adenylyl cyclase may be caused by mutations affecting two elements of the cAMP pathway, the TSH receptor, or the Gs protein itself ...gain of function mutations of TSH receptors or Gs. Moreover, we provide biochemical and molecular evidence for the induction of specific PDE isoforms in the presence of constitutive activation of the cAMP cascade induced by these oncogenes. ...the ATAs bearing constitutively active mutant TSH receptors" ;
    prov:wasQuotedFrom pubmed:10946896 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10946896 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:29:52.041+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}