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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#_9 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#_8 http://www.w3.org/ns/prov#value To identify potential physiological inducers of IKKepsilon, a dominant-negative version of each of the three IkB kinases was cotransfected with an NF-kB reporter gene into HeLa cells, which were then treated with TNFalpha or IL-1 (Figure 4A). Consistent with previous work ( [30, 37 and 46]), the dominant-negative IKKalpha (dnIKKalpha) slightly inhibited the activation of the NF-kB reporter gene by TNFalpha and IL-1, while the dnIKKbeta virtually abolished NF-kB activation by both inducers. http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10882136 http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10882136 http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#_8 http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY#pubinfo http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY http://purl.org/dc/terms/created 2014-07-03T14:29:51.553+02:00 http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArRtYMWx6gK8iUZV2a616oDUra80PvfXxnIfEUB1lMoY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234