http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#Head http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#provenance http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#pubinfo http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_2 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9352 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.ebi.ac.uk/chebi/searchId.do?chebiId=26523 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_1 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(HGNC:PRDX1)) -| a(CHEBI:"reactive oxygen species") http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_4 http://www.w3.org/ns/prov#value Hydrogen peroxide is implicated as an intracellular messenger in various cellular responses such as proliferation and differentiation. Peroxiredoxin (Prx) I is a member of the peroxiredoxin family of peroxidases and contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin-dependent kinases (CDKs). This protein has now been shown to be phosphorylated specifically on Thr(90) by several CDKs, including Cdc2, in vitro. Phosphorylation of Prx I on Thr(90) reduced the peroxidase activity of this protein by 80%. The phosphorylation of Prx I in HeLa cells was monitored with the use of antibodies specific for Prx I phosphorylated on Thr(90). Immunoblot analysis with these antibodies of HeLa cells arrested at various stages of the cell cycle revealed that Prx I phosphorylation occurs in parallel with the activation of Cdc2; Prx I phosphorylation was thus marked during mitosis but virtually undetectable during interphase. Furthermore, when Cdc2 expression was reduced by RNA interference with cognate small interfering RNAs, Prx I phosphorylation was not observed in the cells synchronized in mitotic phase. The cytosolic location of Prx I likely prevents its interaction with activated CDKs until after the breakdown of the nuclear envelope during mitosis, when Cdc2 is the CDK that is most active. Phosphorylation of Prx I on Thr(90) both in vitro and in vivo was blocked by roscovitine, an inhibitor of CDKs. These results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H(2)O(2) might be important for progression of the cell cycle. http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11986303 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11986303 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#_4 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU#pubinfo http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://purl.org/dc/terms/created 2014-07-03T14:30:02.829+02:00 http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArZasHmBzz9MhFuZEl7bqa-dXpVJJ65YU3IMB2FY1NFU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234