http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#Head http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#provenance http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#pubinfo http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88244 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D007668 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_1 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0006972 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"hyperosmotic response") -> r(MGI:S100a8) http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_3 http://www.w3.org/ns/prov#value Osmolality of the mammalian renal medulla is high because of the operation of the urinary concentrating mechanism. To understand molecular events during the early phase of cellular adaptation to hypertonicity, we performed comprehensive searches for genes induced in response to hypertonicity using a cell line (mIMCD3) derived from the inner medullary collecting duct of mouse kidney. PCR-based subtractive hybridization of cDNA pools and cDNA microarray analysis were used. We report 12 genes whose mRNA expression is significantly increased within 4 h after exposure to hypertonicity. The increase in mRNA expression was the result of increased transcription. Many are either stress response genes or growth regulatory genes, supporting the notion that hypertonicity evokes the stress response and growth regulation in cells. Experiments using inhibitors revealed that mitogen-activated protein kinases were commonly involved in signaling for the induction of genes by hypertonicity. Tyrosine kinases and phosphatidylinositol 3-kinase also play a significant role. Signaling pathways for stimulation of transcription appeared quite diverse in that each gene was sensitive to different combinations of inhibitors. http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11742797 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11742797 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#_3 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI#pubinfo http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://purl.org/dc/terms/created 2014-07-03T14:29:59.719+02:00 http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArZiUYDHlG4M5DCFQHOArBri_XPkm0cJ61o7ojKnlyBI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234