sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.6" .
  sub:_5 prov:value """Adhesion of HT-29 cells on a monolayer of HUVEC pretreated with TNFα was dependent
on E-selectin expression but was independent of SAPK2/p38 activity of both HUVEC
and tumor cells. The adhesion of HT-29 cells to E-selectin-expressing HUVEC led
to the activation of SAPK2/p38 in the tumor cells as reflected by the increased
phosphorylation of the actin-polymerizing factor HSP27 by mitogen-activated protein
kinase 2/3, a direct target of SAPK2/p38. Moreover, a recombinant E-selectin/Fc
chimera quickly increased the activation of SAPK2/p38 in HT-29 cells. Blocking
the increased activity of SAPK2/p38 of HT-29 cells by SB203580 or by expressing
a dominant negative form of SAPK2/p38 inhibited their transendothelial migration.""" ;
    prov:wasQuotedFrom pubmed:11448946 .
  sub:_6 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11448946 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}