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[Amyloid-? may not be the only active component of AD neurotoxicity and may involve other proteolytic APP fragments such as the APP intracellular domain, proposed to work as a transcription factor involved in the regulation of p53 and glycogen synthase kinase 3? (GSK3?) as well as affecting several physiological processes contributing to AD pathology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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