sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Serine 167 in AF1 is also phosphorylated, this time by the 90-kDa ribosomal S6 kinase RSK 89, which is itself activated by ERK1 and ERK2. Another signalling pathway that might have an important role in ER activity is the phosphatidylinositol- 3-OH kinase (PI3K) signalling pathway. The serine/threonine protein kinase AKT (or PKB) is one of the downstream targets of PI3K97. Its activation promotes cellular proliferation and anti-apoptotic responses. ER phosphorylation by AKT occurs at serine 167 and results in ligand-independent activation of ER98,99." ;
    prov:wasQuotedFrom pubmed:12635173 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12635173 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}