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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAsTeWSM2C1lWMqz582uQO02xGEW_4KW3vUdTgV9Gy4fA#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAsTeWSM2C1lWMqz582uQO02xGEW_4KW3vUdTgV9Gy4fA#_6 http://www.w3.org/ns/prov#value In human thyroid tissue, the ligand-independent activation of the adenylyl cyclase may be caused by mutations affecting two elements of the cAMP pathway, the TSH receptor, or the Gs protein itself ...gain of function mutations of TSH receptors or Gs. 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