sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "1.4" .
  sub:_7 prov:value "background: (from text) Axin-1 is a negative regulator of the Wnt pathway that controls the levels of the transcriptional activator ?-catenin (Behrens et al., 1996). In the absence of Wnt signals, ?-catenin is degraded by an Axin-1-containing multiprotein complex , while activation of the pathway with, e.g., dishevelled (Dvl) inhibits ?-catenin degradation and induces Lef/Tcf-dependent transcription (Huelsken and Birchmeier, 2001).   evidence: (from text) In the assay, moderate overexpression of Dvl in HEK293 cells caused a 4-fold increase in reporter gene activity. However, this increase was reduced to 1.5-fold in a dose-dependent manner, when full-length ANP32A or CRMP1 were coexpressed (Figure 6C). The activity of protein fragments in the Wnt signaling assay correlated with their ability to bind Axin-1. " ;
    prov:wasQuotedFrom pubmed:16169070 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16169070 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}