. . . . . . . . . . . . . . . . . . . . "complex(p(HGNC:CRMP1),p(HGNC:AXIN1)) -| tscript(p(HGNC:CTNNB1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "background: (from text) Axin-1 is a negative regulator of the Wnt pathway that controls the levels of the transcriptional activator ?-catenin (Behrens et al., 1996). In the absence of Wnt signals, ?-catenin is degraded by an Axin-1-containing multiprotein complex , while activation of the pathway with, e.g., dishevelled (Dvl) inhibits ?-catenin degradation and induces Lef/Tcf-dependent transcription (Huelsken and Birchmeier, 2001). evidence: (from text) In the assay, moderate overexpression of Dvl in HEK293 cells caused a 4-fold increase in reporter gene activity. However, this increase was reduced to 1.5-fold in a dose-dependent manner, when full-length ANP32A or CRMP1 were coexpressed (Figure 6C). The activity of protein fragments in the Wnt signaling assay correlated with their ability to bind Axin-1. " . . "Selventa" . . . . "2014-07-03T14:30:38.176+02:00"^^ . . .