. . . . . . . . . . . . . . "bp(GO:\"response to hypoxia\") -> tscript(p(HGNC:HIF1A))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Indeed, the proportion of cardiac output that goes to adipose tissue is decreased in obesity, and the obese do not show the post-prandial increase in blood flow which occurs in lean individuals (Karpe et al. 2002). Activation of a transcription factor, hypoxia inducible factor-1 (HIF-1), through the stimulation of the expression of the HIF-1a subunit - the molecular sensor of hypoxia (Semenza 2001, Wenger 2002, Hopfl et al. 2004) - may be the mechanism through which low oxygen tension links to inflammation (Trayhurn & Wood 2004). The target genes for HIF-1 include VEGF and leptin, and expression of both of these has been shown to be stimulated in 3T3-L1 adipocytes in response to hypoxia (Lolmede et al. 2003)." . . "Selventa" . . . . "2014-07-03T14:30:36.893+02:00"^^ . . .