sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "A COX-2-selective inhibitor, NS-398 (10 µM), was used to determine whether COX-2 was responsible for the observed increases in PGE2 synthesis by CSE-treated fibroblasts (62). Two different strains of human lung fibroblasts were pretreated with NS-398 for 1 h before treatment with 1% CSE for 24 h, and supernatants were analyzed for PGE2. As shown in Fig. 2, the fibroblast strains incubated with 1% CSE had a three- to fourfold induction in PGE2 synthesis over basal levels after 24 h, depending on the strain. However, cells treated with both CSE and NS-398 had significantly decreased PGE2 levels relative to fibroblasts treated with CSE alone, supporting the idea that the elevated PGE2 levels are a result of COX-2 activity. " ;
    prov:wasQuotedFrom pubmed:15234907 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15234907 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}