@prefix dct: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: mgi:1278315;
    a Protein: .
  
  sub:_2 geneProductOf: mgi:88276;
    a Protein: .
  
  sub:_3 occursIn: species:10090;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(MGI:Lrp5) -> p(MGI:Ctnnb1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "Two different constructs of LRP5 were made in which the cytoplasmic tail (LRP5deltaC) or the transmembrane domain and cytoplasmic tail (LRP5deltaTM) were deleted. The two dominant-negative forms decreased ALP activity induced by Wnt3a in both C3H10T1/2 and ST2 cells strongly suggesting that LRP5 modulates the inducing effect of Wnt3a. It was also seen that LRP5deltaC and LRP5deltaTM significantly inhibited the induction of ALP by BMP2 in ST2 AND C3H10T1/2 cells. Moreover, ST2 cells that were stably expressing LRP5deltaC(LRP5deltaC-ST2) were less able to express ALP in response to either Wnt3a or BMP2, compared to ST2 cells stably expressing wild-type LRP5 (LRP5-ST2).";
    prov:wasQuotedFrom pubmed:11719191 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11719191;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:59.304+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}