http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#Head http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#provenance http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1278315 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88276 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_2 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_1 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Lrp5) -> p(MGI:Ctnnb1) http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_4 http://www.w3.org/ns/prov#value Two different constructs of LRP5 were made in which the cytoplasmic tail (LRP5deltaC) or the transmembrane domain and cytoplasmic tail (LRP5deltaTM) were deleted. The two dominant-negative forms decreased ALP activity induced by Wnt3a in both C3H10T1/2 and ST2 cells strongly suggesting that LRP5 modulates the inducing effect of Wnt3a. It was also seen that LRP5deltaC and LRP5deltaTM significantly inhibited the induction of ALP by BMP2 in ST2 AND C3H10T1/2 cells. Moreover, ST2 cells that were stably expressing LRP5deltaC(LRP5deltaC-ST2) were less able to express ALP in response to either Wnt3a or BMP2, compared to ST2 cells stably expressing wild-type LRP5 (LRP5-ST2). http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11719191 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11719191 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#_4 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://purl.org/dc/terms/created 2014-07-03T14:29:59.304+02:00 http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtEo23UcWNvTRcfqNw7Lt1cfz35iOiIm1D1ZRsoQ0Fus http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234