[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_1",
    "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0043234" ],
    "http://purl.obolibrary.org/obo/BFO_0000051" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_2"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_3"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_2",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:103034"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_3",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:1276523"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_4",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:1276116"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_5",
    "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0042789" ],
    "http://semanticscience.org/resource/SIO_000139" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_6"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_6",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:103034"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_7",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_5"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/increases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_1"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "complex(p(MGI:Stat6),p(MGI:Ncoa1),p(MGI:Ep300)) -> tscript(p(MGI:Stat6))"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_9"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "1.4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_8",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "Transcriptional activation by signal transducer and activator of transcription 6 (STAT6) has been shown to require the direct interaction not only with co-activators such as p300 and cAMP-responsive element-binding protein-binding protein (CBP) but also with nuclear co-activator 1, a member of the p160/steroid receptor co-activator family. Among the p160/steroid receptor co-activators, only p/CIP (nuclear co-activator 3) has been shown to be up-regulated by interleukin (IL)-4 in B cells through a STAT-6-dependent mechanism using Gene-Chip analysis. In this study, we have investigated the function of p/CIP in the transcriptional activation by STAT6. We found that p/CIP indirectly interacted with STAT6 via p300, and overexpression of the CBP-interacting domain of p/CIP (p/CIP(947-1084)) prevented the interaction of p/CIP with STAT6 by blocking the binding of p/CIP to p300. Whereas expression of p/CIP(947-1084) resulted in a marked reduction of STAT6-mediated transactivation, overexpression of wild type p/CIP resulted in significant enhancement of it. In addition, p/CIP(947-1084) markedly reduced CD23 expression on B cells stimulated with IL-4, whereas overexpression of wild type p/CIP enhanced it. Chromatin immunoprecipitations demonstrate that IL-4 increases the interaction of p/CIP with the murine immunoglobulin heavy chain germ line epsilon promoter in B cells. These results suggest that p/CIP positively regulates STAT6 transcriptional activation through formation of a STAT6, p300/CBP, and p/CIP complex."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15145939"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_9",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15145939"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_8"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:30:23.439+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#pubinfo"
} ]