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http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_9 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_8 http://www.w3.org/ns/prov#value Transcriptional activation by signal transducer and activator of transcription 6 (STAT6) has been shown to require the direct interaction not only with co-activators such as p300 and cAMP-responsive element-binding protein-binding protein (CBP) but also with nuclear co-activator 1, a member of the p160/steroid receptor co-activator family. Among the p160/steroid receptor co-activators, only p/CIP (nuclear co-activator 3) has been shown to be up-regulated by interleukin (IL)-4 in B cells through a STAT-6-dependent mechanism using Gene-Chip analysis. In this study, we have investigated the function of p/CIP in the transcriptional activation by STAT6. We found that p/CIP indirectly interacted with STAT6 via p300, and overexpression of the CBP-interacting domain of p/CIP (p/CIP(947-1084)) prevented the interaction of p/CIP with STAT6 by blocking the binding of p/CIP to p300. Whereas expression of p/CIP(947-1084) resulted in a marked reduction of STAT6-mediated transactivation, overexpression of wild type p/CIP resulted in significant enhancement of it. In addition, p/CIP(947-1084) markedly reduced CD23 expression on B cells stimulated with IL-4, whereas overexpression of wild type p/CIP enhanced it. Chromatin immunoprecipitations demonstrate that IL-4 increases the interaction of p/CIP with the murine immunoglobulin heavy chain germ line epsilon promoter in B cells. These results suggest that p/CIP positively regulates STAT6 transcriptional activation through formation of a STAT6, p300/CBP, and p/CIP complex. http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15145939 http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15145939 http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#_8 http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI http://purl.org/dc/terms/created 2014-07-03T14:30:23.439+02:00 http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAt_7MIUvjxsUuC0NvWIHTsqdXD40npmiwFiYFCdfyjFI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234